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FIRST PUBLICATION FROM BARRICAID LEVEL-1 RCT OUT

October 16, 2017

On August 28 the Journal of Pain Research (Journal Impact Factor 2.581) reported that placement of a bone-anchored anular closure device (ACD) following lumbar discectomy significantly reduces reoperation risk within 90 days of discharge.

As perioperative complications place a large financial burden on patients, hospitals and payers, there is a large incentive to reduce early complication rates, both in-hospital and following patient discharge.

The purpose of this post hoc analysis of a level 1b randomized trial was to evaluate perioperative complications of lumbar discectomy with or without a bone-anchored annular closure device (ACD/Barricaid) implant in patients at high risk of recurrent disc herniation.

272 patients treated with ACD and 278 patients treated with lumbar discectomy alone were analyzed for Serious Adverse Events (SAEs) and reoperations within 90 days of discharge.

90-day perioperative SAEs and reoperation risk
  Barricaid Control p-value*
All-cause Serious Adverse Event (SAE) 9.7% 16.3% 0.056
Device- or procedure-related SAE 4.5% 10.2% 0.02
Index-level reoperation 1.9% 5.4% 0.03
*log-rank test

Conclusion: In patients undergoing lumbar discectomy to treat symptomatic intervertebral disc herniation, adjunctive placement of an ACD reduces the risk for perioperative complications occurring through 90 days following hospital discharge.

The article ‘Bone-anchored annular closure following lumbar discectomy reduces risk of complications and reoperations within 90 days of discharge’ is open access and can be downloaded here.

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